Activating or Inhibiting Nrf2?

Xin-Yi Chu; Ye-Mao Liu; Hong-Yu Zhang

doi:10.1016/j.tips.2017.08.002

Activating or Inhibiting Nrf2?

Trends Pharmacol Sci. 2017 Nov;38(11):953-955. doi: 10.1016/j.tips.2017.08.002. Epub 2017 Sep 5.

Authors

Xin-Yi Chu¹, Ye-Mao Liu¹, Hong-Yu Zhang²

Affiliations

¹ Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China.
² Hubei Key Laboratory of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: zhy630@mail.hzau.edu.cn.

PMID: 28886953
DOI: 10.1016/j.tips.2017.08.002

Abstract

Activating nuclear factor erythroid 2 (NF-E2)-related factor (Nrf2) is a widely recognized strategy for combating oxidative-stress-induced diseases. However, Nrf2 activation does not always bring advantageous effects. Therefore, before performing Nrf2-targeted therapy, we must pinpoint whether Nrf2 should be activated or inhibited.

Keywords: Nrf2; activator; inhibitor; oxidative stress.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Metabolic Diseases / drug therapy
Metabolic Diseases / metabolism
Metabolic Networks and Pathways / drug effects
NF-E2-Related Factor 2 / antagonists & inhibitors*
NF-E2-Related Factor 2 / metabolism*
Neoplasms / drug therapy
Neoplasms / metabolism
Neurodegenerative Diseases / drug therapy
Neurodegenerative Diseases / metabolism
Oxidative Stress / drug effects

Substances

NF-E2-Related Factor 2