Bioactive Dental Composites and Bonding Agents Having Remineralizing and Antibacterial Characteristics

Ke Zhang; Ning Zhang; Michael D Weir; Mark A Reynolds; Yuxing Bai; Hockin H K Xu

doi:10.1016/j.cden.2017.05.002

Bioactive Dental Composites and Bonding Agents Having Remineralizing and Antibacterial Characteristics

Dent Clin North Am. 2017 Oct;61(4):669-687. doi: 10.1016/j.cden.2017.05.002.

Authors

Ke Zhang¹, Ning Zhang¹, Michael D Weir², Mark A Reynolds², Yuxing Bai³, Hockin H K Xu⁴

Affiliations

¹ Department of Orthodontics, School of Stomatology, Capital Medical University, 4 Tiantanxili Street, Beijing 100050, China; Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
² Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.
³ Department of Orthodontics, School of Stomatology, Capital Medical University, 4 Tiantanxili Street, Beijing 100050, China. Electronic address: byuxing@263.net.
⁴ Department of Endodontics, Periodontics and Prosthodontics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, 655 West Baltimore Street, Baltimore, MD 21201, USA; Department of Mechanical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Cir, Baltimore County, MD 21250, USA. Electronic address: hxu@umaryland.edu.

Abstract

Current dental restorative materials are typically inert and replace missing tooth structures. This article reviews efforts in the development of a new generation of bioactive materials designed to not only replace the missing tooth volume but also possess therapeutic functions. Composites and bonding agents with remineralizing and antibacterial characteristics have shown promise in replacing lost minerals, inhibiting recurrent caries, neutralizing acids, repelling proteins, and suppressing biofilms and acid production. Furthermore, they have demonstrated a low cytotoxicity similar to current resins, with additional benefits to protect the dental pulp and promote tertiary dentin formation. This new class of bioactive materials shows promise in reversing lesions and inhibiting caries.

Keywords: Antibacterial monomers; Bioactive composites; Bonding agents; Calcium phosphate nanoparticles; Caries inhibition; Oral biofilms; Remineralization; Silver nanoparticles.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Composite Resins / pharmacology*
Dental Materials / pharmacology*
Dentin-Bonding Agents / pharmacology*
Humans
Tooth Remineralization*

Substances

Anti-Bacterial Agents
Composite Resins
Dental Materials
Dentin-Bonding Agents

Grants and funding

R01 DE017974/DE/NIDCR NIH HHS/United States