Monitoring of Recommended Metabolic Laboratory Parameters Among Medicaid Recipients on Second-Generation Antipsychotics in Federally Qualified Health Centers

Ann Pharmacother. 2018 Feb;52(2):160-165. doi: 10.1177/1060028017731421. Epub 2017 Sep 8.

Abstract

Background: In 2004, a consensus statement outlining recommended metabolic monitoring for patients prescribed second-generation antipsychotics (SGAs) was published. More than a decade later, suboptimal adherence rates to these recommendations continue to be reported, which could lead to long-term and costly complications.

Objectives: To define the prevalence of appropriately monitored Medicaid patients receiving care at federally qualified health centers (FQHCs) prescribed SGAs.

Methods: This was a retrospective study examining electronic health record and Medicaid claims data to assess the rates of glucose and lipid monitoring for patients prescribed SGAs from January 2014 to August 2016 in a FQHC. Prescription and laboratory claims for patients receiving care at 4 FQHCs were reviewed. Descriptive statistics were used to evaluate the primary outcome.

Results: A total of 235 patients were included in the analysis. Patients initiated on SGA therapy (n = 92) had baseline glucose and lipid monitoring rates of 50% and 23%, respectively. The 3-month monitoring rates were 37% for glucose and 26% for lipids, whereas annual rates were 71% and 40%, respectively. Patients continuing SGA therapy (n = 143) had annual glucose and lipid monitoring rates of 67% and 44%.

Conclusions: Medicaid patients at FQHCs initially prescribed SGAs have low baseline and 3-month metabolic monitoring, whereas annual monitoring was comparable to previously published studies. Adults receiving chronic care at a FQHC were more likely to receive glucose monitoring. Those with type 2 diabetes mellitus and/or hyperlipidemia were more likely to receive glucose and lipid monitoring.

Keywords: antipsychotics (atypical); drug monitoring diabetes; lipids; therapeutic monitoring; type 2.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Ambulatory Care Facilities
  • Antipsychotic Agents / therapeutic use*
  • Blood Glucose / analysis*
  • Child
  • Child, Preschool
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy
  • Female
  • Humans
  • Hyperlipidemias / blood
  • Hyperlipidemias / drug therapy
  • Lipids / blood*
  • Male
  • Medicaid
  • Middle Aged
  • Monitoring, Physiologic*
  • Retrospective Studies
  • United States
  • Young Adult

Substances

  • Antipsychotic Agents
  • Blood Glucose
  • Lipids