Recent advances in polysaccharides for osteoarthritis therapy

Qixin Chen; Xintian Shao; Peixue Ling; Fei Liu; Guanying Han; Fengshan Wang

doi:10.1016/j.ejmech.2017.08.048

Recent advances in polysaccharides for osteoarthritis therapy

Eur J Med Chem. 2017 Oct 20:139:926-935. doi: 10.1016/j.ejmech.2017.08.048. Epub 2017 Aug 24.

Authors

Qixin Chen¹, Xintian Shao¹, Peixue Ling², Fei Liu³, Guanying Han⁴, Fengshan Wang⁵

Affiliations

¹ Shandong Academy of Pharmaceutical Science, Shandong Provincial Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide Drugs, Jinan 250101, China; School of Pharmaceutical Sciences, Shandong University, Jinan 250101, China.
² Shandong Academy of Pharmaceutical Science, Shandong Provincial Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide Drugs, Jinan 250101, China; School of Pharmaceutical Sciences, Shandong University, Jinan 250101, China. Electronic address: lpxsdf@163.com.
³ Shandong Academy of Pharmaceutical Science, Shandong Provincial Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide Drugs, Jinan 250101, China; School of Pharmaceutical Sciences, Shandong University, Jinan 250101, China. Electronic address: lfshwu@163.com.
⁴ Shandong Academy of Pharmaceutical Science, Shandong Provincial Key Laboratory of Biopharmaceuticals, Engineering Laboratory of Polysaccharide Drugs, National-Local Joint Engineering Laboratory of Polysaccharide Drugs, Jinan 250101, China; The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China; Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
⁵ School of Pharmaceutical Sciences, Shandong University, Jinan 250101, China. Electronic address: fswang@sdu.edu.cn.

PMID: 28881287
DOI: 10.1016/j.ejmech.2017.08.048

Abstract

The polysaccharides used in the treatment of osteoarthritis (OA) mainly include sodium hyaluronate, chondroitin sulfate, chitosan, xanthan gum, Low molecular weight heparin, alginate and other polysaccharides. This review summarizes the recent advances in the chemistry and biological activities of polysaccharides for the treatment of OA.

Keywords: Osteoarthritis; Polysaccharides; Therapy.

Publication types

Review

MeSH terms

Animals
Carbohydrate Conformation
Humans
Osteoarthritis / drug therapy*
Polysaccharides / chemistry
Polysaccharides / therapeutic use*

Substances

Polysaccharides