Human T-lymphotropic Virus Type II Infection inVietnamese Thalassemic Patients

M T Lin; B T Nguyen; T V Binh; T V Be; T Y Chiang; L H Tseng; Y C Yang; K H Lin; Y -C Chen

doi:10.1007/s007050050170

Human T-lymphotropic Virus Type II Infection inVietnamese Thalassemic Patients

Arch Virol. 1997 Jul;142(7):1429-1440. doi: 10.1007/s007050050170.

Authors

M T Lin¹, B T Nguyen², T V Binh², T V Be², T Y Chiang³, L H Tseng⁴, Y C Yang⁵, K H Lin⁶, Y -C Chen¹

Affiliations

¹ Departments of Oncology, Hematology Center, Ho Chi Minh City, Veitnam, Vietnam.
² Blood Transfusion Hematology Center, Ho Chi Minh City, Veitnam, Vietnam.
³ Institute of Botany, Academia Sinica, Taipei, Taiwan, Taiwan.
⁴ Medical Genetics,Graduate Institutes of Microbiology and School of Medical Technology, College of Medicine, National Taiwan University, Taipei, Taiwan, Taiwan.
⁵ Graduate Institutes of Microbiology and School of Medical Technology, College of Medicine, National Taiwan University, Taipei, Taiwan, Taiwan.
⁶ Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, Taiwan.

PMID: 28879400
DOI: 10.1007/s007050050170

Abstract

Anti-human T-lymphotropic virus type I/II (HTLV-I/II) antibodies were screened by particle agglutination test in a total of 66 patients with thalassemia major who received multiple transfusion from paid donors at the Blood Transfusion Hematology Center of Ho Chi Minh City in South Vietnam. HTLV-II infection was confirmed in 6 patients (9.1%) by Western blot analysis and/or polymerase chain reaction. Phylogenetic analysis revealed that long terminal repeat sequences of HTLV-II proviruses from 5 thalassemic patients in Vietnam belonged to the same phylogenetic subgroup of HTLV-IIb as those from intravenous drug abusers in North America and Europe. These data shed light on the route of introducing HTLV-II into Vietnam.