Intravascular large B-cell lymphoma presenting as Richter's syndrome with cerebral involvement in a patient with chronic lymphocytic leukemia

Robert Puckrin; Paula Pop; Zeina Ghorab; Julia Keith; Lisa Chodirker; Yulia Lin; Jeannie Callum

doi:10.1002/ccr3.1087

Intravascular large B-cell lymphoma presenting as Richter's syndrome with cerebral involvement in a patient with chronic lymphocytic leukemia

Clin Case Rep. 2017 Jul 20;5(9):1444-1449. doi: 10.1002/ccr3.1087. eCollection 2017 Sep.

Authors

Robert Puckrin¹, Paula Pop¹, Zeina Ghorab², Julia Keith², Lisa Chodirker³, Yulia Lin⁴, Jeannie Callum⁴

Affiliations

¹ Postgraduate Medical Education University of Toronto Toronto Ontario Canada.
² Department of Anatomic Pathology Sunnybrook Health Sciences Centre Toronto Ontario Canada.
³ Department of Hematology Sunnybrook Health Sciences Centre Toronto Ontario Canada.
⁴ Department of Clinical Pathology Sunnybrook Health Sciences Centre Toronto Ontario Canada.

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is an aggressive non-Hodgkin's lymphoma which can present with B symptoms, rash, and neurological deterioration. Up to 10% of cases of IVLBCL are associated with other hematological neoplasms, including this extremely rare presentation of IVLBCL as Richter's transformation in chronic lymphocytic leukemia.

Keywords: Chronic lymphocytic leukemia; Richter's transformation; intravascular large B‐cell lymphoma; meningeal lymphomatosis.

Publication types

Case Reports