Corneal Collagen Cross-Linking Complications

Semin Ophthalmol. 2018;33(1):29-35. doi: 10.1080/08820538.2017.1353809. Epub 2017 Sep 6.

Abstract

Corneal cross-linking was approved by United States Food and Drug Administration for the treatment of progressive keratoconus in April 2016. As this approach becomes more widely used for the treatment of keratoconus and post-laser in situ keratomileusis (LASIK) ectasia, the medical community is becoming more familiar with potential complications associated with this procedure. This article aims to review the reported complications of collagen cross-linking for the treatment of keratoconus and post-LASIK ectasia.

Keywords: Ectasia; epi-off; epi-on; keratoconus (KCN); post-LASIK ectasia; transepithelial cross-linking (TE CXL).

Publication types

  • Review

MeSH terms

  • Collagen / adverse effects*
  • Collagen / therapeutic use
  • Corneal Stroma / drug effects*
  • Corneal Stroma / pathology
  • Corneal Topography
  • Cross-Linking Reagents / adverse effects*
  • Cross-Linking Reagents / therapeutic use
  • Dilatation, Pathologic / chemically induced
  • Dilatation, Pathologic / pathology
  • Humans
  • Keratoconus / drug therapy*
  • Keratoconus / pathology
  • Photochemotherapy / adverse effects*
  • Ultraviolet Rays
  • Visual Acuity

Substances

  • Cross-Linking Reagents
  • Collagen