Altered glycosylation is a universal feature of cancer cells, and certain glycans are well-known markers of tumor progression. This chapter discusses glycan biosynthetic pathways that are frequently altered in cancer cells; correlations between altered glycosylation, diagnosis, and clinical prognosis; the genetic bases of some of these changes; and studies indicating their pathological importance.
Copyright 2015-2017 by The Consortium of Glycobiology Editors, La Jolla, California. All rights reserved.