The phenomenon of "remote synchronization" (RS), first observed in a star network of oscillators, involves synchronization of unconnected peripheral nodes through a hub that maintains independent dynamics. In the RS regime the central hub was thought to serve as a passive gate for information transfer between nodes. Here, we investigate the physical origin of this phenomenon. Surprisingly, we find that a hub node can drive remote synchronization of peripheral oscillators even in the presence of a repulsive mean field, thus actively governing network dynamics while remaining asynchronous. We study this novel phenomenon in complex networks endowed with multiple hub-nodes, a ubiquitous feature of many real-world systems, including brain connectivity networks. We show that a change in the natural frequency of a single hub can alone reshape synchronization patterns across the entire network, and switch from direct to remote synchronization, or to hub-driven desynchronization. Hub-driven RS may provide a mechanism to account for the role of structural hubs in the organization of brain functional connectivity networks.