Bisoprolol-induced thrombocytopenia: A case report

J Clin Pharm Ther. 2018 Apr;43(2):280-283. doi: 10.1111/jcpt.12614. Epub 2017 Sep 3.

Abstract

What is known and objective: Thrombocytopenia, not associated with bone marrow primary disease, is a common clinical problem. The possibility of drug-induced thrombocytopenia must be considered, especially in hospitalized patients. Drugs can cause thrombocytopenia by several mechanisms including direct bone marrow or other organ toxicity, and immune reactions.

Case description: We describe a patient presenting with thrombocytopenia likely related to bisoprolol.

What is new and conclusion: We report a case of bisoprolol-induced thrombocytopenia which resolved with drug discontinuation and steroid therapy. We review the mechanisms involved in drug-induced immune thrombocytopenia.

Keywords: antibodies; bisoprolol; case report; thrombocytopenia.

Publication types

  • Case Reports

MeSH terms

  • Antihypertensive Agents / adverse effects*
  • Bisoprolol / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Thrombocytopenia / chemically induced*

Substances

  • Antihypertensive Agents
  • Bisoprolol