Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.
Keywords: BAF180; Clear Cell Kidney Cancer Mouse Model; Genomic Biomarkers; MTOR; PBRM1; SWI/SNF Chromatin Remodeling Tumor Suppressor Gene; VHL.