New Iridoids from Scrophularia ningpoensis

Chem Pharm Bull (Tokyo). 2017;65(9):869-873. doi: 10.1248/cpb.c17-00163.

Abstract

Five new compounds including five iridoids (1-5) and six known compounds were isolated from the rhizomes of Scrophularia ningpoensis. Their structures were determined by extensive NMR and IR, MS spectroscopic data analyses. The anti-inflammatory, antibacterial, antifungal, and cytotoxic activities of the isolated compounds were evaluated. Compound 11 exhibited significant inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells.

Keywords: Scrophularia ningpoensis; anti-inflammatory; iridoid; pyrrolidin-2-one.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / isolation & purification
  • Anti-Inflammatory Agents / pharmacology
  • Iridoids / chemistry*
  • Iridoids / isolation & purification
  • Lipopolysaccharides / toxicity
  • Macrophages / cytology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Molecular Conformation
  • Nitric Oxide / metabolism
  • RAW 264.7 Cells
  • Rhizome / chemistry
  • Rhizome / metabolism
  • Scrophularia / chemistry*
  • Scrophularia / metabolism
  • Spectrophotometry, Infrared

Substances

  • Anti-Inflammatory Agents
  • Iridoids
  • Lipopolysaccharides
  • Nitric Oxide