Key themes and future prospects in translational multiple system atrophy research

S Eschlboeck; F Krismer; G K Wenning

doi:10.1016/j.autneu.2017.08.004

Key themes and future prospects in translational multiple system atrophy research

Auton Neurosci. 2018 May:211:43-45. doi: 10.1016/j.autneu.2017.08.004. Epub 2017 Aug 12.

Authors

S Eschlboeck¹, F Krismer¹, G K Wenning²

Affiliations

¹ Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
² Department of Neurology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria. Electronic address: gregor.wenning@i-med.ac.at.

PMID: 28867372
DOI: 10.1016/j.autneu.2017.08.004

Abstract

Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disorder with a highly variable clinical presentation. Unfortunately, there exists no effective therapy that can improve the course of the disease and symptomatic treatment options remain limited. Although significant progress in research has improved our understanding of MSA, knowledge gaps still remain. Thus, a global network focusing on different research areas is required to face this fatal disease.

Keywords: Clinical trials; Multiple system atrophy; Synucleinopathies; Therapies.

Publication types

Review

MeSH terms

Animals
Biomarkers / analysis
Clinical Trials as Topic*
Disease Models, Animal
Humans
Multiple System Atrophy / diagnosis
Multiple System Atrophy / therapy*
Translational Research, Biomedical*
alpha-Synuclein / metabolism*

Substances

Biomarkers
alpha-Synuclein