Alternative polyadenylation in the regulation and dysregulation of gene expression

Rachael Emily Turner; Andrew David Pattison; Traude Helene Beilharz

doi:10.1016/j.semcdb.2017.08.056

Alternative polyadenylation in the regulation and dysregulation of gene expression

Semin Cell Dev Biol. 2018 Mar:75:61-69. doi: 10.1016/j.semcdb.2017.08.056. Epub 2017 Sep 1.

Authors

Rachael Emily Turner¹, Andrew David Pattison¹, Traude Helene Beilharz²

Affiliations

¹ Development and stem cells Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, 3800, Australia.
² Development and stem cells Program, Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, Victoria, 3800, Australia. Electronic address: traude.beilharz@monash.edu.

PMID: 28867199
DOI: 10.1016/j.semcdb.2017.08.056

Abstract

Transcriptional control shapes a cell's transcriptome composition, but it is RNA processing that refines its expression. The untranslated regions (UTRs) of mRNA are hotspots for regulatory control. Features in these can impact mRNA stability, localisation and translation. Here we describe how alternative cleavage and polyadenylation can change mRNA fate by changing the length of its 3'UTR.

Keywords: 3'UTR; 3’-End formation; Alternative polyadenylation; Poly(A)-tail.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

3' Untranslated Regions / genetics*
Alternative Splicing*
Animals
Gene Expression Regulation*
Humans
Models, Genetic
Polyadenylation / genetics*
Protein Biosynthesis
RNA Isoforms / genetics
RNA Stability

Substances

3' Untranslated Regions
RNA Isoforms