Are organosilicon surfactants safe for bees or humans?

Abstract

Organosilicon surfactants are the most potent adjuvants available for formulating and applying agricultural pesticides and fertilizers, household cleaning and personal care products, dental impressions and medicines. Risk assessment of pesticides, drugs or personal care products that takes into account only active ingredients without the other formulation ingredients and adjuvants commonly used in their application will miss important toxicity outcomes detrimental to non-target species including pollinators and humans. Over a billion pounds of organosilicon surfactants from all uses are produced globally per year, making this a major component of the chemical landscape to which bees and humans are exposed. These silicones, like most "inerts", are generally recognized as safe, have no mandated tolerances, and their residues are largely unmonitored. Lack of their public disclosure and adequate analytical methods constrains evaluation of their risk. Organosilicon surfactants, the most super-spreading and -penetrating adjuvants available, at relevant exposure levels impair honey bee learning, are acutely toxic, and in combination with bee viruses cause synergistic mortality. Organosilicon surfactants need to be regulated as a separate class of "inerts" from the more common silicones. In turn, impacts of organosilicon surfactant exposures on humans need to be evaluated. Silicones in their great diversity probably represent the single most ubiquitous environmental class of global synthetic pollutants. Do honey bees, a model environmental indicator organism, forewarn of hidden risks to humans of ubiquitous silicone exposures?

Keywords: Adjuvant; Bee toxicity; Non-target effects; Organosilicon surfactant; Personal care products; Silicones.