Methods of Protein Misfolding Cyclic Amplification

Methods Mol Biol. 2017:1658:169-183. doi: 10.1007/978-1-4939-7244-9_13.

Abstract

Protein misfolding cyclic amplification (PMCA) amplifies infectious prions in vitro. Over the past decade, PMCA has become an essential tool in prion research. The current chapter describes in detail the PMCA format with beads (PMCAb) and several methods that rely on PMCAb for assessing strain-specific prion amplification rates, for selective amplification of subtypes of PrPSc from a mixture, and a PMCAb approach that can replace animal titration of scrapie material. Development of PMCAb-based methodology is important for addressing a number of research topics including prion strain evolution, selection and adaptation, strain-typing, prion detection, and biochemical requirements for prion replication.

Keywords: Prion detection; Prion diseases; Prion protein; Prion strains; Protein misfolding cyclic amplification; Replication rate; Self-propagating protein states; Sonication.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Biological Assay*
  • Brain / metabolism
  • Brain / pathology
  • Brain Chemistry
  • Cricetulus
  • Endopeptidase K / chemistry
  • Gene Expression
  • Humans
  • Microspheres
  • PrPC Proteins / chemistry*
  • PrPC Proteins / genetics
  • PrPC Proteins / metabolism
  • PrPSc Proteins / chemistry*
  • PrPSc Proteins / genetics
  • PrPSc Proteins / metabolism
  • Protein Folding
  • RNA / genetics
  • RNA / metabolism
  • Ribonuclease, Pancreatic / chemistry
  • Scrapie / genetics*
  • Scrapie / metabolism
  • Scrapie / pathology
  • Sonication / methods*
  • Weaning

Substances

  • PrPC Proteins
  • PrPSc Proteins
  • RNA
  • Ribonuclease, Pancreatic
  • Endopeptidase K