Histamine and Toll-like receptor ligands synergistically induce endothelial cell gap formation by the extrinsic coagulating pathway

J Allergy Clin Immunol. 2018 Mar;141(3):1115-1118.e7. doi: 10.1016/j.jaci.2017.07.026. Epub 2017 Aug 30.

Authors

Yuhki Yanase¹, Satoshi Morioke¹, Kazumasa Iwamoto¹, Shunsuke Takahagi¹, Kazue Uchida¹, Tomoko Kawaguchi¹, Kaori Ishii¹, Izumi Hide², Michihiro Hide³

Affiliations

¹ Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
² Department of Molecular and Pharmacological Neuroscience, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
³ Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan. Electronic address: ed1h-w1de-road@hiroshima-u.ac.jp.

PMID: 28859973
DOI: 10.1016/j.jaci.2017.07.026

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Blood Coagulation / drug effects*
Blood Coagulation / genetics
Chronic Disease
Gene Expression Regulation / drug effects*
Histamine / pharmacology*
Human Umbilical Vein Endothelial Cells
Humans
Ligands
Lipopolysaccharides / toxicity*
Mast Cells / metabolism
Mast Cells / pathology
Thromboplastin / biosynthesis*
Thromboplastin / genetics
Toll-Like Receptors / genetics
Toll-Like Receptors / metabolism*
Urticaria / genetics
Urticaria / metabolism*
Urticaria / pathology

Substances

Ligands
Lipopolysaccharides
Toll-Like Receptors
Histamine
Thromboplastin