Novel secolignans from Peperomia dindygulensis and their inhibitory activities on JAK-STAT signaling pathways

Fitoterapia. 2017 Oct:122:80-84. doi: 10.1016/j.fitote.2017.08.018. Epub 2017 Aug 30.

Abstract

Nineteen secolignans (1-19), including five new ones (1-5), were isolated from the whole plant of Peperomia dindygulensis. Their structures including stereochemistry were determined by spectroscopic methods, in particular NMR and electronic CD (ECD) analysis. All the isolates were evaluated for their inhibitory activities against IFN-γ/STAT1 as well as IL-6/STAT3 signaling pathway by the method of Luciferase assay. Six 2-methene type secolignans (1, 2, 6-9) exhibited significant inhibitory activities against JAK-STAT pathways with the IC50 values both lower than 10μM.

Keywords: IFN-γ/STAT1 signaling pathway; IL-6/STAT3 signaling pathway; Peperomia dindygulensis; Secolignans.

MeSH terms

  • Hep G2 Cells
  • Humans
  • Interleukin-6 / metabolism
  • Lignans / pharmacology*
  • Molecular Structure
  • Peperomia / chemistry*
  • STAT1 Transcription Factor / metabolism
  • STAT3 Transcription Factor / metabolism
  • Signal Transduction / drug effects*

Substances

  • IL6 protein, human
  • Interleukin-6
  • Lignans
  • STAT1 Transcription Factor
  • STAT1 protein, human
  • STAT3 Transcription Factor
  • STAT3 protein, human