Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter

Marco Antonio Briones-Orta; S Eréndira Avendaño-Vázquez; Diana Ivette Aparicio-Bautista; Jason D Coombes; Georg F Weber; Wing-Kin Syn

doi:10.1016/j.dib.2017.07.057

Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter

Data Brief. 2017 Aug 2:14:538-542. doi: 10.1016/j.dib.2017.07.057. eCollection 2017 Oct.

Authors

Marco Antonio Briones-Orta¹, S Eréndira Avendaño-Vázquez², Diana Ivette Aparicio-Bautista², Jason D Coombes¹, Georg F Weber³, Wing-Kin Syn^{1

4

5}

Affiliations

¹ Regeneration and Repair, Institute of Hepatology, Foundation for Liver Research, London, United Kingdom.
² Instituto Nacional de Medicina Genómica, INMEGEN, Periférico Sur 4809, Ciudad de México 14610,. México.
³ James L. Winkle College of Pharmacy, University of Cincinnati Academic Health Center, Cincinnati, OH, United States.
⁴ Division of Gastroenterology and Hepatology, Department of Medicine, Medical University of South Carolina, Charleston, SC, United States.
⁵ Section of Gastroenterology, Ralph H Johnson Veteran Affairs Medical Center, Charleston, SC, United States.

Abstract

This data contains information related to the research article entitled "Osteopontin splice variants and polymorphisms in Cancer Progression and Prognosis" [1]. Here, we describe an in silico analysis of transcription factors that could have altered binding to their DNA target sequence as a result of SNPs in the osteopontin gene promoter. We concentrated on SNPs associated with cancer risk and development. The analysis was performed with PROMO v3.0.2 software which incorporates TRANSFACT v6.4 of. We also present a figure depicting the putative transcription factor binding according to genotype.