Biomimetic Synthesis of Lankacidin Antibiotics

Kuan Zheng; Defeng Shen; Ran Hong

doi:10.1021/jacs.7b08500

Biomimetic Synthesis of Lankacidin Antibiotics

J Am Chem Soc. 2017 Sep 20;139(37):12939-12942. doi: 10.1021/jacs.7b08500. Epub 2017 Sep 6.

Authors

Kuan Zheng^{1

2}, Defeng Shen^{1

2}, Ran Hong¹

Affiliations

¹ Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
² University of Chinese Academy of Sciences , 19A Yuquan Road, Beijing 100049, China.

PMID: 28853876
DOI: 10.1021/jacs.7b08500

Abstract

We devised short syntheses of lankacidinol and lankacyclinol that feature biomimetic Mannich macrocyclization. The modular construction of the carbon framework of these compounds is amenable to rapid structural diversification for the development of antibiotic and antitumor agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Biomimetic Materials / chemical synthesis*
Biomimetic Materials / chemistry
Macrolides / chemical synthesis*
Macrolides / chemistry
Molecular Structure

Substances

Anti-Bacterial Agents
Macrolides
lankacidins