Synthesis and Optimization of MoS2@Fe3O4-ICG/Pt(IV) Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser

Bei Liu; Chunxia Li; Guanying Chen; Bin Liu; Xiaoran Deng; Yi Wei; Jun Xia; Bengang Xing; Ping'an Ma; Jun Lin

doi:10.1002/advs.201600540

Synthesis and Optimization of MoS₂@Fe₃O₄-ICG/Pt(IV) Nanoflowers for MR/IR/PA Bioimaging and Combined PTT/PDT/Chemotherapy Triggered by 808 nm Laser

Adv Sci (Weinh). 2017 Apr 10;4(8):1600540. doi: 10.1002/advs.201600540. eCollection 2017 Aug.

Authors

Bei Liu^{1

2}, Chunxia Li³, Guanying Chen⁴, Bin Liu^{1

2}, Xiaoran Deng^{1

2}, Yi Wei^{1

2}, Jun Xia⁴, Bengang Xing⁵, Ping'an Ma¹, Jun Lin¹

Affiliations

¹ State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China.
² University of the Chinese Academy of Sciences Beijing 100049 China.
³ College of Chemistry and Life Sciences Zhejiang Normal University Jinhua 321004 China.
⁴ Institute for Lasers Photonics and Biophotonics University at Buffalo The State University of New York NY 14260 United States.
⁵ School of Physical and Mathematical Sciences Nanyang Technological University 637371 Singapore Singapore.

Abstract

Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS₂ nanoflowers with a broad size range of 80-180 nm have been synthesized through a facile, controllable, and scalable hydrothermal method. The strong absorbance of MoS₂ nanoflowers at 808 nm imparts them with high efficiency and stability of photothermal conversion. Then a novel multifunctional composite of MoS₂@Fe₃O₄-ICG/Pt(IV) (labeled as Mo@Fe-ICG/Pt) is designed by covalently grafting Fe₃O₄ nanoparticles with polyethylenimine (PEI) functionalized MoS₂, and then loading indocyanine green molecules (ICG, photosensitizers) and platinum (IV) prodrugs (labeled as Pt(IV) prodrugs) on the surface of MoS₂@Fe₃O₄. The resulting Mo@Fe-ICG/Pt nanocomposites can achieve excellent magnetic resonance/infrared thermal/photoacoustic trimodal biomaging as well as remarkably enhanced antitumor efficacy of combined photothermal therapy, photodynamic therapy, and chemotherapy triggered by a single 808 nm NIR laser, thus leading to an ideal nanoplatform for cancer diagnosis and treatment in future.

Keywords: 808 nm; MoS2 nanoflowers; bioimaging; combined therapy; size control.