Topological Defects in Hyperbranched Glycopolymers Enhance Binding to Lectins

Abstract

Central scaffold topology and carbohydrate density are important features in determining the binding mechanism and potency of synthetic multivalent of poly- versus monodisperse carbohydrate systems against a model plant toxin (Ricinus communis agglutinin (RCA₁₂₀ )). Lower densities of protein receptors favour the use of heterogeneous, polydisperse glycoconjugate presentations, as determined by surface plasmon resonance and dynamic light scattering.

Keywords: carbohydrates; dendrimers; glycoconjugates; molecular recognition; multivalency.