Journey Heading towards Enantioselective Synthesis Assisted by Organocatalysis

Jasneet Kaur; Pankaj Chauhan; Sarbjit Singh; Swapandeep Singh Chimni

doi:10.1002/tcr.201700020

Journey Heading towards Enantioselective Synthesis Assisted by Organocatalysis

Chem Rec. 2018 Feb;18(2):137-153. doi: 10.1002/tcr.201700020. Epub 2017 Aug 29.

Authors

Jasneet Kaur¹, Pankaj Chauhan², Sarbjit Singh³, Swapandeep Singh Chimni¹

Affiliations

¹ Department of Chemistry, U.G.C. Centre of Advanced Studies in Chemistry, Guru Nanak Dev University, Amritsar, India.
² Institute of Organic Chemistry, RWTH Aachen University, Germany.
³ Department of Chemistry, University of Texas at Dallas, USA.

PMID: 28851023
DOI: 10.1002/tcr.201700020

Abstract

This personal account summarizes the design of various organocatalysts derived from amino acids and Cinchona alkaloids and their applications in enantioselective carbon-carbon and carbon-nitrogen bond formation reactions. This account begins with the short description of the background of asymmetric organocatalysis. Various types of reactions like aldol reaction, Michael reaction, aza-Henry reaction, Morita-Baylis-Hillman reaction are described in this account.

Keywords: Cinchona alkaloid; enantioselective; isatin; organocatalysis; oxindole.

Publication types

Review