NO-Donor Iron Nitrosyl Complex with N-Ethylthiourea Ligand Exhibits Selective Toxicity to Glioma A172 Cells

Molecules. 2017 Aug 29;22(9):1426. doi: 10.3390/molecules22091426.

Abstract

We studied effects of NO-donor iron nitrosyl complex with N-ethylthiourea ligand (ETM) on normal or tumor-derived cell lines. ETM was mildly toxic to most cell lines studied except the human glioma cell line A172 that proved to be highly sensitive to the complex and underwent cell death after ETM exposure. The high susceptibility of A172 cells to ETM was attributed to its NO-donor properties since no toxicity was detected for the N-ethylthiourea ligand.

Keywords: N-ethylthiourea; NO donor; cytotoxicity; glioma; iron nitrosyl complex; nitric oxide.

MeSH terms

  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cell Survival / drug effects
  • Glioma / drug therapy
  • Glioma / metabolism*
  • Humans
  • Iron / chemistry*
  • Ligands
  • Molecular Structure
  • Nitric Oxide / metabolism*
  • Nitrogen Oxides / chemistry*
  • Thiourea / analogs & derivatives*
  • Thiourea / chemistry
  • Thiourea / pharmacology

Substances

  • Ligands
  • Nitrogen Oxides
  • Nitric Oxide
  • N-ethylthiourea
  • dinitrosyl iron complex
  • Iron
  • Thiourea