Synthesis of Chondroitin Sulfate A Bearing Syndecan-1 Glycopeptide

Org Lett. 2017 Sep 15;19(18):4838-4841. doi: 10.1021/acs.orglett.7b02271. Epub 2017 Aug 29.

Abstract

Syndecan-1 chondroitin sulfate glycopeptide was synthesized for the first time using the cassette approach. The sequence of glycosylation to form the octasaccharide serine cassette was critical. The glycopeptide was successfully assembled via a 2+ (3 + 3) glycosylation strategy followed by peptide chain elongation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Chondroitin Sulfates / chemistry*
  • Glycopeptides
  • Glycosylation
  • Heparitin Sulfate
  • Molecular Structure
  • Proteoglycans
  • Syndecan-1

Substances

  • Glycopeptides
  • Proteoglycans
  • Syndecan-1
  • Chondroitin Sulfates
  • Heparitin Sulfate