In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared with Those of Five Antifungal Drugs against Melanized Fungi and Relatives

Gholam Reza Shokoohi; Hamid Badali; Hossein Mirhendi; Saham Ansari; Ali Rezaei-Matehkolaei; Bahram Ahmadi; Afsane Vaezi; Mohamed Mahdi Alshahni; Koichi Makimura

doi:10.1128/AAC.00635-17

In Vitro Activities of Luliconazole, Lanoconazole, and Efinaconazole Compared with Those of Five Antifungal Drugs against Melanized Fungi and Relatives

Antimicrob Agents Chemother. 2017 Oct 24;61(11):e00635-17. doi: 10.1128/AAC.00635-17. Print 2017 Nov.

Authors

Gholam Reza Shokoohi¹, Hamid Badali², Hossein Mirhendi³, Saham Ansari⁴, Ali Rezaei-Matehkolaei⁵, Bahram Ahmadi⁶, Afsane Vaezi^{2

7}, Mohamed Mahdi Alshahni⁸, Koichi Makimura⁸

Affiliations

¹ Department of Medical Parasitology and Mycology, School of Public Health, National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran.
² Department of Medical Mycology and Parasitology, Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
³ Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran mirhendi@tums.ac.ir.
⁴ Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁵ Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁶ Department of Microbiology and Parasitology, School of Para-Medicine, Bushehr University of Medical Sciences, Bushehr, Iran.
⁷ Student Research Committee Center, Mazandaran University of Medical Sciences, Sari, Iran.
⁸ Laboratory of Space and Environmental Medicine, Graduate School of Medicine, Teikyo University, Tokyo, Japan.

Abstract

The in vitro activities of novel azoles compared to those of five antifungal drugs against clinical (n = 28) and environmental (n = 102) isolates of black mold and melanized yeast were determined. Luliconazole and lanoconazole had the lowest geometric mean MICs, followed by efinaconazole, against tested isolates compared to the other drugs. Therefore, it appears that these new imidazole and triazole drugs are promising candidates for the treatment of infections due to melanized fungi and their relatives.

Keywords: MIC; efinaconazole; in vitro; lanoconazole; luliconazole; melanized fungi.

Publication types

Comparative Study

MeSH terms

Adult
Antifungal Agents / pharmacology*
Ascomycota / drug effects*
Ascomycota / isolation & purification
Child, Preschool
Drug Resistance, Fungal / genetics
Female
Humans
Imidazoles / pharmacology*
Male
Microbial Sensitivity Tests
Middle Aged
Mycoses / drug therapy
Triazoles / pharmacology*
Yeasts / drug effects*
Young Adult

Substances

Antifungal Agents
Imidazoles
Triazoles
latoconazole
efinaconazole
luliconazole