RanBPM: a potential therapeutic target for modulating diverse physiological disorders

Soumyadip Das; Bharathi Suresh; Hyongbum Henry Kim; Suresh Ramakrishna

doi:10.1016/j.drudis.2017.08.005

RanBPM: a potential therapeutic target for modulating diverse physiological disorders

Drug Discov Today. 2017 Dec;22(12):1816-1824. doi: 10.1016/j.drudis.2017.08.005. Epub 2017 Aug 26.

Authors

Soumyadip Das¹, Bharathi Suresh², Hyongbum Henry Kim³, Suresh Ramakrishna⁴

Affiliations

¹ Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea.
² Department of Pharmacology, Yonsei University College of Medicine, Seoul, 03722, South Korea. Electronic address: bharathi.suri@gmail.com.
³ Department of Pharmacology, Yonsei University College of Medicine, Seoul, 03722, South Korea; Brain Korea 21 Plus Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, South Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, 03722, South Korea; Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, 03722, South Korea. Electronic address: hkim1@yuh.ac.
⁴ Graduate School of Biomedical Science and Engineering, Hanyang University, Seoul, 04763, South Korea; College of Medicine, Hanyang University, Seoul, 04763, South Korea. Electronic address: suri28@hanyang.ac.kr.

PMID: 28847759
DOI: 10.1016/j.drudis.2017.08.005

Abstract

The Ran-binding protein microtubule-organizing center (RanBPM) is a highly conserved nucleocytoplasmic protein involved in a variety of intracellular signaling pathways that control diverse cellular functions. RanBPM interacts with proteins that are linked to various diseases, including Alzheimer's disease (AD), schizophrenia (SCZ), and cancer. In this article, we define the characteristics of the scaffolding protein RanBPM and focus on its interaction partners in diverse physiological disorders, such as neurological diseases, fertility disorders, and cancer.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / chemistry
Adaptor Proteins, Signal Transducing / metabolism*
Animals
Brain Diseases / metabolism
Cytoskeletal Proteins / chemistry
Cytoskeletal Proteins / metabolism*
Humans
Neoplasms / metabolism
Nuclear Proteins / chemistry
Nuclear Proteins / metabolism*
Reproduction / physiology

Substances

Adaptor Proteins, Signal Transducing
Cytoskeletal Proteins
Nuclear Proteins
Ran binding protein 9