Protein-protein Interactions and their Role in Various Diseases and their Prediction Techniques

Abstract

Protein-protein interaction (PPI) is necessary for most of the biological processes and requisite for host-pathogen communication. Most of the threatening human diseases are caused by different types of interactions of proteins with their prior infected proteins or with pathogen's proteins. Understanding of involved mechanisms of interacting pairs, functional domains and characterizing specific molecular interaction of host and pathogen is critical. In this era of advanced research in medical and pharmaceutical sciences, the treatment of severe diseases is being tackled at genetic and PPI level. In this review, a brief introduction and application of PPI is described. Moreover, the classifications of PPI and their application in diseases are highlighted. Furthermore, methods for prediction of PPI are also discussed including brief introduction and update on detection techniques. We hope this review will prove to be very helpful for researchers to get better understanding and update on PPI.

Keywords: Computation tools; disease; drug design; effector molecule; protein-protein interactions; structure..