Lactoferricin/verbascoside topical emulsion: a possible alternative treatment for atopic dermatitis in dogs

Nat Prod Res. 2018 Sep;32(17):2107-2110. doi: 10.1080/14786419.2017.1365066. Epub 2017 Aug 28.

Abstract

Atopic dermatitis affects 3-15% of the general dog population and it has been diagnosed by veterinarians up to 58% of dogs affected with skin disease. It is usually a life-long pathology which can be controlled, but it can be seldom cured. The present investigation describes a case study in which lactoferricin and verbascoside are part of a formulation to obtain a dermatological lotion for canine dermatitis treatment. The study was an open-label trial design of two-week treatment. Thirty-eight dogs (23 females and 15 males), with atopic dermatitis and secondary bacterial or yeast overgrowth have been included. During treatment period the total clinical score progressively decreased associated with an improvement in clinical signs. No adverse effects were reported in any of the treated dogs. The present research suggests that daily applications of tested emulsion are effective in reducing bacterial overgrowth and clinical signs in skin folds and atopic dermatitis.

Keywords: Lactoferricin; atopic dermatitis; dog; verbascoside.

MeSH terms

  • Animals
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / veterinary
  • Dog Diseases / drug therapy*
  • Dogs
  • Drug Combinations
  • Emulsions / chemistry
  • Emulsions / therapeutic use
  • Female
  • Glucosides / therapeutic use*
  • Lactoferrin / therapeutic use*
  • Male
  • Phenols / therapeutic use*
  • Treatment Outcome

Substances

  • Drug Combinations
  • Emulsions
  • Glucosides
  • Phenols
  • lactoferricin B
  • acteoside
  • Lactoferrin