ERS statement on protracted bacterial bronchitis in children

Ahmad Kantar; Anne B Chang; Mike D Shields; Julie M Marchant; Keith Grimwood; Jonathan Grigg; Kostas N Priftis; Renato Cutrera; Fabio Midulla; Paul L P Brand; Mark L Everard

doi:10.1183/13993003.02139-2016

ERS statement on protracted bacterial bronchitis in children

Eur Respir J. 2017 Aug 24;50(2):1602139. doi: 10.1183/13993003.02139-2016. Print 2017 Aug.

Authors

Ahmad Kantar^{1

2}, Anne B Chang^{3

4

5

2}, Mike D Shields⁶, Julie M Marchant^{3

4}, Keith Grimwood⁷, Jonathan Grigg⁸, Kostas N Priftis⁹, Renato Cutrera¹⁰, Fabio Midulla¹¹, Paul L P Brand¹², Mark L Everard¹³

Affiliations

¹ Pediatric Asthma and Cough Centre, Istituti Ospedalieri Bergamaschi, University and Research Hospitals, Bergamo, Italy kantar@centropediatricotosse.com.
² Both authors contributed equally.
³ Dept of Respiratory and Sleep Medicine, Lady Cilento Children's Hospital, Brisbane, Australia.
⁴ Centre for Children's Health Research, Institute of Health & Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
⁵ Child Health Division, Menzies School of Health Research, Charles Darwin University, Casuarina, Australia.
⁶ Dept of Child Health, Queen's University Belfast, Belfast, UK.
⁷ Menzies Health Institute Queensland, Griffith University and Gold Coast Health, Gold Coast, Australia.
⁸ Blizard Institute, Queen Mary University London, London, UK.
⁹ Third Dept of Paediatrics, University General Hospital Attikon, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
¹⁰ Respiratory Unit, University Dept of Pediatrics, Bambino Gesu' Children's Research Hospital, Rome, Italy.
¹¹ Dept of Pediatrics and Infantile Neuropsychiatry, "Sapienza" University of Rome, Rome, Italy.
¹² Isala Women and Children's Hospital, Zwolle, the Netherlands.
¹³ School of Pediatrics and Child Health, University of Western Australia, Princess Margaret Hospital, Subiaco, Australia.

PMID: 28838975
DOI: 10.1183/13993003.02139-2016

Abstract

This European Respiratory Society statement provides a comprehensive overview on protracted bacterial bronchitis (PBB) in children. A task force of experts, consisting of clinicians from Europe and Australia who manage children with PBB determined the overall scope of this statement through consensus. Systematic reviews addressing key questions were undertaken, diagrams in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement constructed and findings of relevant studies summarised. The final content of this statement was agreed upon by all members.The current knowledge regarding PBB is presented, including the definition, microbiology data, known pathobiology, bronchoalveolar lavage findings and treatment strategies to manage these children. Evidence for the definition of PBB was sought specifically and presented. In addition, the task force identified several major clinical areas in PBB requiring further research, including collecting more prospective data to better identify the disease burden within the community, determining its natural history, a better understanding of the underlying disease mechanisms and how to optimise its treatment, with a particular requirement for randomised controlled trials to be conducted in primary care.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Australia
Bacterial Infections* / diagnosis
Bacterial Infections* / physiopathology
Bacterial Infections* / therapy
Bronchitis* / diagnosis
Bronchitis* / microbiology
Bronchitis* / physiopathology
Bronchitis* / therapy
Bronchoalveolar Lavage Fluid / microbiology
Bronchoscopy / methods
Child
Disease Management
Europe
Humans
Practice Guidelines as Topic

Substances

Anti-Bacterial Agents

Grants and funding

G1000758/MRC_/Medical Research Council/United Kingdom