Mouse Models of Corneal Scarring

Laure Rittié; Audrey E K Hutcheon; James D Zieske

doi:10.1007/978-1-4939-7113-8_8

Mouse Models of Corneal Scarring

Methods Mol Biol. 2017:1627:117-122. doi: 10.1007/978-1-4939-7113-8_8.

Authors

Laure Rittié^{1

2}, Audrey E K Hutcheon³, James D Zieske⁴

Affiliations

¹ Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
² Dermatology Therapeutic Area, GlaxoSmithKline, Collegeville, PA, USA.
³ Schepens Eye Research Institute/MEE and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA.
⁴ Schepens Eye Research Institute/MEE and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. James_zieske@meei.harvard.edu.

PMID: 28836198
DOI: 10.1007/978-1-4939-7113-8_8

Abstract

Corneal scarring is an obligatory consequence of stroma corneal injury and is a major cause of decreased visual quality and vision loss worldwide. There are currently no satisfactory intervention therapies for corneal fibrosis. In this chapter, we describe well-established in vivo corneal wound models to allow researchers to investigate epithelial and stromal responses to corneal injury.

Keywords: Cornea; Epithelial debridement; Incision; Keratectomy; Mouse.

MeSH terms

Animals
Cicatrix / diagnosis
Cicatrix / etiology*
Cicatrix / pathology*
Cornea / pathology
Corneal Diseases / diagnosis
Corneal Diseases / etiology*
Corneal Diseases / pathology*
Disease Models, Animal*
Epithelium, Corneal / pathology
Mice
Microscopy, Fluorescence
Slit Lamp

Abstract

MeSH terms

Grants and funding