AMP-activated protein kinase: a therapeutic target in intestinal diseases

Open Biol. 2017 Aug;7(8):170104. doi: 10.1098/rsob.170104.

Abstract

Adenosine monophosphate (AMP)-activated protein kinase (AMPK), a highly conserved energy sensor, has a crucial role in cardiovascular, neurodegenerative and inflammatory diseases, as well as in cancer and metabolic disorders. Accumulating studies have demonstrated that AMPK activation enhances paracellular junctions, nutrient transporters, autophagy and apoptosis, and suppresses inflammation and carcinogenesis in the intestine, indicating an essential role of AMPK in intestinal health. AMPK inactivation is an aetiological factor in intestinal dysfunctions. This review summarizes the favourable outcomes of AMPK activation on intestinal health, and discusses AMPK as a potential therapeutic target for intestinal diseases.

Keywords: AMPK; absorption; barrier function; colorectal cancer; intestinal health; intestinal inflammation.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use
  • Autophagy
  • Enzyme Activation*
  • Humans
  • Intestinal Absorption
  • Intestinal Diseases / drug therapy
  • Intestinal Diseases / enzymology*
  • Signal Transduction / drug effects

Substances

  • Anti-Inflammatory Agents
  • AMP-Activated Protein Kinases