Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review

Floor A M Postema; Saskia M J Hopman; Raoul C Hennekam; Johannes H M Merks

doi:10.1002/pbc.26718

Consequences of diagnosing a tumor predisposition syndrome in children with cancer: A literature review

Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26718. Epub 2017 Aug 22.

Authors

Floor A M Postema¹, Saskia M J Hopman^{1

2}, Raoul C Hennekam³, Johannes H M Merks¹

Affiliations

¹ Department of Pediatric Oncology, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.
² Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.
³ Department of Pediatrics, Emma Children's Hospital, Academic Medical Center, Amsterdam, The Netherlands.

PMID: 28834056
DOI: 10.1002/pbc.26718

Abstract

Up to 8.5% of children with cancer have a genetic cause for their cancer: a tumor predisposition syndrome (TPS). Diagnosing a TPS is of great importance, as it may have major consequences for clinical care. Patients with TPSs require specific monitoring and management. We present an overview of the cancer-related and noncancer-related consequences for the 36 most common TPSs.

Keywords: cancer; consequences; genetic predisposition to disease; pediatrics.

Publication types

Review

MeSH terms

Adolescent
Child
Child, Preschool
Female
Genetic Predisposition to Disease
Humans
Infant
Male
Neoplastic Syndromes, Hereditary / genetics*