From cholesterol to consciousness

Prog Biophys Mol Biol. 2018 Jan:132:52-56. doi: 10.1016/j.pbiomolbio.2017.08.009. Epub 2017 Aug 19.

Abstract

The nature of consciousness has been debated for centuries. It can be understood as part and parcel of the natural progression of life from unicellular to multicellular, calcium fluxes mediating communication within and between cells. Consciousness is the vertical integration of calcium fluxes, mediated by the Target of Rapamycin gene integrated with the cytoskeleton. The premise of this paper is that there is a fundamental physiologic integration of the organism with the environment that constitutes consciousness.

Keywords: Calcium flux; Cell-cell communication; Consciousness; Cytoskeleton; Target of Rapamycin.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Communication
  • Cholesterol / metabolism*
  • Consciousness*
  • Cytoskeleton / metabolism
  • Humans
  • Neurons / cytology
  • Neurons / metabolism
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • Cholesterol
  • TOR Serine-Threonine Kinases