Lipid Profile of Children Suffering from Pediatric Rheumatic Diseases (pRDS)

Abstract

Background: Aim of this study was to assess the lipid status of the patients of pediatric rheumatologic diseases (pRDS).

Methods: This observational study was carried out in the department of pediatrics, Khulna medical college hospital, Bangladesh for a period of one year. Total 23 patients were included in this study. These new cases were diagnosed according to the ILAR, ACR, and EULAR criteria. Early morning blood samples were sent to the laboratory for the assessment of lipid status (TC, TG, HDL, and LDL). These values were collected and statistically recorded.

Results: Total new cases of pRDS were 23. Among them JIA was 15, SLE 4, and Vasculitis 4 in number. HSP was in 3 and KD in 1 cases of vasculitis group. Male/ Female ratio is 1.6:1. Mean age of the diseases were 8.54 years. TC, and TG was found in significant level in 4(17.4%), and 12(52.8%) pRDS cases respectively. HDL was observed of risk level in 4(17.3%) patients. LDL was observed normal in all the patients. TG was found of significant level in 7(46.7%) JIA, 3(75%) SLE and 2 (50%) vasculitis patients.

Conclusion: TG was the lipid observed in significant level in majority of the new pRDS cases. Elevated TG might be considered as an index of disease activity in all cases of pRDS. Measures could be adopted in all pRDS to control the lipid status from the beginning of illness to reduce the complications from dyslipidemia like atherosclerosis and cardiovascular morbidity and mortality in future.

Keywords: Lipid profile; atherosclerosis; cardiovascular morbidity; dyslipidemia; elevated TG; pediatric rheumatic disease..