Abstract
One new diphenyl ether, diorcinol K (1), along with three known compounds, diorcinols D (2), F (3) and I (4) were isolated from the fermentation media of a marine-derived fungus Aspergillus sp. CUGB-F046 which was isolated from a sediment sample collected from the Bohai Sea, China. Their structures were elucidated by detailed spectroscopic methods. Compounds 1, 2 and 4 displayed significant antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus with MIC values of 3.125, 6.25 and 6.25 μg/mL, respectively.
Keywords:
Aspergillus sp; MRSA; isolation; structure elucidation.
MeSH terms
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / pharmacology*
-
Aquatic Organisms
-
Aspergillus / chemistry*
-
Aspergillus / isolation & purification
-
Aspergillus / metabolism
-
China
-
Drug Evaluation, Preclinical / methods
-
Geologic Sediments / microbiology
-
Magnetic Resonance Spectroscopy
-
Methicillin-Resistant Staphylococcus aureus / drug effects
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Phenols / chemistry
-
Phenols / pharmacology
-
Phenyl Ethers / chemistry*
-
Phenyl Ethers / pharmacology
-
Secondary Metabolism
-
Staphylococcus aureus / drug effects
Substances
-
Anti-Bacterial Agents
-
Phenols
-
Phenyl Ethers
-
diorcinol D