Diphenyl ethers from a marine-derived isolate of Aspergillus sp. CUGB-F046

Nat Prod Res. 2018 Apr;32(7):821-825. doi: 10.1080/14786419.2017.1363754. Epub 2017 Aug 22.

Abstract

One new diphenyl ether, diorcinol K (1), along with three known compounds, diorcinols D (2), F (3) and I (4) were isolated from the fermentation media of a marine-derived fungus Aspergillus sp. CUGB-F046 which was isolated from a sediment sample collected from the Bohai Sea, China. Their structures were elucidated by detailed spectroscopic methods. Compounds 1, 2 and 4 displayed significant antibacterial activities against Staphylococcus aureus and methicillin-resistant S. aureus with MIC values of 3.125, 6.25 and 6.25 μg/mL, respectively.

Keywords: Aspergillus sp; MRSA; isolation; structure elucidation.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Aquatic Organisms
  • Aspergillus / chemistry*
  • Aspergillus / isolation & purification
  • Aspergillus / metabolism
  • China
  • Drug Evaluation, Preclinical / methods
  • Geologic Sediments / microbiology
  • Magnetic Resonance Spectroscopy
  • Methicillin-Resistant Staphylococcus aureus / drug effects
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Phenols / chemistry
  • Phenols / pharmacology
  • Phenyl Ethers / chemistry*
  • Phenyl Ethers / pharmacology
  • Secondary Metabolism
  • Staphylococcus aureus / drug effects

Substances

  • Anti-Bacterial Agents
  • Phenols
  • Phenyl Ethers
  • diorcinol D