Epigenetic regulation of somatic cell reprogramming

Yixuan Wang; Yan Bi; Shaorong Gao

doi:10.1016/j.gde.2017.07.002

Epigenetic regulation of somatic cell reprogramming

Curr Opin Genet Dev. 2017 Oct:46:156-163. doi: 10.1016/j.gde.2017.07.002. Epub 2017 Aug 17.

Authors

Yixuan Wang¹, Yan Bi², Shaorong Gao³

Affiliations

¹ Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address: wangyixuan@tongji.edu.cn.
² Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.
³ Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China. Electronic address: gaoshaorong@tongji.edu.cn.

PMID: 28823984
DOI: 10.1016/j.gde.2017.07.002

Abstract

Pluripotent stem cells, having self-renewal capacities and multi-lineage differentiation abilities, offer great potential in disease modeling and therapeutic applications. The successful generation of induced pluripotent stem cells (iPSCs) by the Yamanaka group in 2006 is a milestone event in both reprogramming and stem cell research fields, which makes in vitro somatic cell reprogramming and personalized stem cell therapy feasible. During the past 10 years, several important progresses have been made in uncovering the molecular mechanisms involved in the reprogramming process, which shed light on improving the reprogramming efficiency and iPSC quality. Here, we briefly review the important progresses in the epigenetic regulation including histone and DNA modifications during somatic cell reprogramming.

Publication types

Review

MeSH terms

Animals
Cell Differentiation / genetics*
Cellular Reprogramming / genetics*
Epigenesis, Genetic*
Gene Expression Regulation, Developmental
Humans
Induced Pluripotent Stem Cells
MicroRNAs / genetics*

Substances

MicroRNAs