MicroRNAs in prostate cancer: Functional role as biomarkers

Rajnee Kanwal; Alexis R Plaga; Xiaoqi Liu; Girish C Shukla; Sanjay Gupta

doi:10.1016/j.canlet.2017.08.011

MicroRNAs in prostate cancer: Functional role as biomarkers

Cancer Lett. 2017 Oct 28:407:9-20. doi: 10.1016/j.canlet.2017.08.011. Epub 2017 Aug 18.

Authors

Rajnee Kanwal¹, Alexis R Plaga², Xiaoqi Liu³, Girish C Shukla², Sanjay Gupta⁴

Affiliations

¹ Department of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA; The Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA; Department of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, USA.
² Center of Gene Regulation in Health and Disease, Cleveland State University, Cleveland, OH, 44115, USA; Department of Biological Sciences, Cleveland State University, Cleveland, OH, 44115, USA.
³ Department of Biochemistry, Purdue University, West Lafayette, IN, 47907, USA.
⁴ Department of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA; The Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA; Department of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, USA; Department of Nutrition, Case Western Reserve University, Cleveland, OH, 44106, USA; Division of General Medical Sciences, Case Comprehensive Cancer Center, Cleveland, OH, 44106, USA. Electronic address: sanjay.gupta@case.edu.

PMID: 28823964
DOI: 10.1016/j.canlet.2017.08.011

Abstract

MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.

Keywords: Androgen receptor; Biomarkers; Castrate-resistant prostate cancer; Non-coding RNA; Oncomirs; Tumor suppressor.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / metabolism*
Gene Expression Regulation, Neoplastic
Humans
Male
MicroRNAs / metabolism
MicroRNAs / physiology*
Prognosis
Prostatic Neoplasms / diagnosis
Prostatic Neoplasms / genetics
Prostatic Neoplasms / metabolism*

Substances

Biomarkers, Tumor
MicroRNAs