Nano-technology contributions towards the development of high performance radioisotope generators: The future promise to meet the continuing clinical demand

Tamer M Sakr; Mohamed F Nawar; T W Fasih; S El-Bayoumy; H A Abd El-Rehim

doi:10.1016/j.apradiso.2017.08.012

Nano-technology contributions towards the development of high performance radioisotope generators: The future promise to meet the continuing clinical demand

Appl Radiat Isot. 2017 Nov:129:67-75. doi: 10.1016/j.apradiso.2017.08.012. Epub 2017 Aug 10.

Authors

Tamer M Sakr¹, Mohamed F Nawar², T W Fasih², S El-Bayoumy², H A Abd El-Rehim³

Affiliations

¹ Radioactive Isotopes and Generators Dept., Hot Labs. Center, Atomic Energy Authority, 13759 Cairo, Egypt; Pharmaceutical Chemistry Department, Faculty of Pharmacy, October University of Modern Sciences and Arts (MSA), Giza, Egypt. Electronic address: tamer_sakr78@yahoo.com.
² Radioactive Isotopes and Generators Dept., Hot Labs. Center, Atomic Energy Authority, 13759 Cairo, Egypt.
³ National Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.

PMID: 28822270
DOI: 10.1016/j.apradiso.2017.08.012

Abstract

Nanostructured materials attracted considerable attention because of its high surface area to volume ratio resulting from their nano-scale dimensions. This class of sorbents is expected to have a potential impact on enhancement the efficacy of radioisotope generators for diagnostic and therapeutic applications in nuclear medicine. This review provides a summary on the importance of nanostructured materials as effective sorbents for the development of clinical-scale radioisotope generators and outlining the assessment of recent developments, key challenges and promising access to the near future.

Keywords: (188)W/(188)Re generators; (68)Ge/(68)Ga generator; (99)Mo/(99)Tc generators; Nano sorbents; Nanotechnology; Radioisotope generators; Radiopharmaceuticals.

Publication types

Review