Effects of realgar (As₄S₄) on degradation of PML-RARA harboring acquired arsenic-resistance mutations

MeSH terms

• Amino Acid Substitution / drug effects
• Amino Acid Substitution / genetics
• Arsenic / therapeutic use*
• Arsenicals / pharmacology*
• Arsenicals / therapeutic use
• Drug Resistance, Neoplasm* / drug effects
• Drug Resistance, Neoplasm* / genetics
• HL-60 Cells
• Humans
• Inhibitory Concentration 50
• Leukemia, Promyelocytic, Acute / drug therapy*
• Leukemia, Promyelocytic, Acute / genetics
• Leukemia, Promyelocytic, Acute / metabolism
• Mutation, Missense* / physiology
• Oncogene Proteins, Fusion / genetics
• Oncogene Proteins, Fusion / metabolism*
• Proteolysis / drug effects*
• SUMO-1 Protein / metabolism
• Sulfides / pharmacology*
• Sulfides / therapeutic use
• Sumoylation / drug effects
• Sumoylation / genetics
• Tumor Cells, Cultured