Metabolic Imaging of Infection

J Nucl Med. 2017 Nov;58(11):1727-1732. doi: 10.2967/jnumed.117.191635. Epub 2017 Aug 17.

Abstract

Metabolic imaging has come to occupy a prominent place in the diagnosis and management of microbial infection. Molecular probes available for infection imaging have undergone a rapid evolution starting with nonspecific agents that accumulate similarly in infection, sterile inflammation, and neoplastic tissue and then extending to more targeted probes that seek to identify specific microbial species. This focus review describes the metabolic and molecular imaging techniques currently available for clinical use in infection imaging and those that have demonstrated promising results in preclinical studies with the potential for clinical applications.

Keywords: anti-microbial; infection; molecular imaging; optical imaging.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents / pharmacokinetics
  • Diagnostic Imaging / methods*
  • Humans
  • Infections / diagnostic imaging*
  • Infections / metabolism*
  • Leukocytes
  • Molecular Imaging
  • Radiopharmaceuticals

Substances

  • Anti-Infective Agents
  • Radiopharmaceuticals