Organic Nanoparticle-Based Combinatory Approaches for Gene Therapy

Brahma N Singh; Prateeksha; Vijai K Gupta; Jieyin Chen; Atanas G Atanasov

doi:10.1016/j.tibtech.2017.07.010

Organic Nanoparticle-Based Combinatory Approaches for Gene Therapy

Trends Biotechnol. 2017 Dec;35(12):1121-1124. doi: 10.1016/j.tibtech.2017.07.010. Epub 2017 Aug 14.

Authors

Brahma N Singh¹, Prateeksha², Vijai K Gupta³, Jieyin Chen⁴, Atanas G Atanasov⁵

Affiliations

¹ Herbal Nanobiotechnology Lab, Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow-226001, India. Electronic address: singhbrahmanand99@gmail.com.
² Herbal Nanobiotechnology Lab, Pharmacognosy and Ethnopharmacology Division, CSIR-National Botanical Research Institute, Lucknow-226001, India.
³ Department of Chemistry and Biotechnology, ERA Chair of Green Chemistry, Tallinn University of Technology, 12618 Tallinn, Estonia. Electronic address: vijaifzd@gmail.com.
⁴ Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
⁵ Institute of Genetics and Animal Breeding, Polish Academy of Sciences, 05-552 Jastrzebiec, Poland; Department of Pharmacognosy, University of Vienna, Vienna 1090, Austria.

PMID: 28818304
DOI: 10.1016/j.tibtech.2017.07.010

Abstract

Engineered organic nanoparticle (ONP)-mediated co-delivery of genes and therapeutic agents is emerging as a powerful tool in the treatment of several genetic and non-genetic disorders. The ONP-based combinatory approach provides a technological platform that delivers genes with chemo/radio/photo/immunotherapies for the prevention or treatment of disease progression.

Publication types

Letter
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Chemistry Techniques, Synthetic
Combined Modality Therapy
Drug Delivery Systems*
Drug Therapy
Gene Transfer Techniques*
Genetic Diseases, Inborn / prevention & control
Genetic Diseases, Inborn / therapy
Genetic Therapy / methods*
Genetic Vectors / chemistry
Humans
Immunotherapy
Liposomes
Nanoparticles / chemistry*
Neoplasms / prevention & control
Neoplasms / therapy
Polymers / chemistry
Polymers / therapeutic use
Radiotherapy

Substances

Liposomes
Polymers