IL-17 polarization of MAIT cells is derived from the activation of two different pathways

Eur J Immunol. 2017 Nov;47(11):2002-2003. doi: 10.1002/eji.201747140.

Abstract

MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome.

Keywords: IL-17; IL-23; IL-7; MAIT cells; RORc; STAT3; Sjogren's Syndrome.

Publication types

  • Letter
  • Comment

MeSH terms

  • Humans
  • Interleukin-17*
  • Interleukin-23
  • Mucosal-Associated Invariant T Cells*
  • Salivary Glands
  • Sjogren's Syndrome

Substances

  • Interleukin-17
  • Interleukin-23