Zebrafish earns its stripes for in vivo ASC speck dynamics

Jelena S Bezbradica; Kate Schroder

doi:10.1083/jcb.201708002

Zebrafish earns its stripes for in vivo ASC speck dynamics

J Cell Biol. 2017 Sep 4;216(9):2615-2618. doi: 10.1083/jcb.201708002. Epub 2017 Aug 15.

Authors

Jelena S Bezbradica¹, Kate Schroder²

Affiliations

¹ The Kennedy Institute of Rheumatology, University of Oxford, Oxford, England, UK jelena.bezbradica@kennedy.ox.ac.uk.
² Centre for Inflammation and Disease Research, Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Brisbane, Australia k.schroder@uq.edu.au.

Abstract

Assembly of the ASC speck is critical for signaling by the inflammasome. In this issue, Kuri et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201703103) use live microscopy to track fluorescently tagged endogenous ASC in the zebrafish, describing the molecular domains driving ASC speck assembly and identifying a key role for macrophages in ASC speck removal in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytoskeletal Proteins*
Inflammasomes
Macrophages
Signal Transduction
Zebrafish*

Substances

Cytoskeletal Proteins
Inflammasomes