We demonstrate a Kerr-lens mode-locked Tm3+:Sc2O3 single-crystal laser in-band pumped by an Er3+:Yb3+ fiber master oscillator power amplifier at 1611 nm. Pulses as short as 166 fs with an average output power of 440 mW are obtained. The spectral bandwidth and center wavelength are 29.3 and 2124 nm, respectively. At a longer pulse duration of 298 fs, we obtain 1 W of average output power. The repetition rate is 95 MHz, and the conversion efficiency against the absorbed pump power is as high as 47%. To the best of our knowledge, this is the first Kerr-lens mode-locked Tm3+-doped solid state laser.