Tagetones A and B, new cytotoxic monocyclic diterpenoids from flowers of Tagetes minuta

Chin J Nat Med. 2017 Jul;15(7):546-549. doi: 10.1016/S1875-5364(17)30081-X.

Abstract

Tagetones A (1) and B (2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Tagetes minuta L. (Asteraceae). Their structures were established by multiple spectroscopic methods (IR, HR-ESI-MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound 1 showed cytotoxic activity towards MCF7 and A549 cancer cells with IC50 values being 4.68 and 4.24 µmol·L-1, respectively, compared to doxorubicin (IC50 0.13 and 1.12 µmol·L-1, respectively). Compound 2 also exhibited significant activity against HCT116 cancer cells (IC50, 6.30 µmol·L-1).

Keywords: Asteraceae; Cytotoxic; Monocyclic diterpenoids; Tagetes minuta; Tagetones.

MeSH terms

  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification
  • Diterpenes / pharmacology*
  • Flowers / chemistry
  • Humans
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Tagetes / chemistry*

Substances

  • Diterpenes
  • Plant Extracts