Plight of the pore polar bar(rier)

Jerod S Denton; Sujay V Kharade

doi:10.1080/19336950.2017.1367234

Plight of the pore polar bar(rier)

Channels (Austin). 2017 Nov 2;11(6):502-503. doi: 10.1080/19336950.2017.1367234. Epub 2017 Aug 25.

Authors

Jerod S Denton^{1

2}, Sujay V Kharade¹

Affiliations

¹ a Department of Anesthesiology , Vanderbilt University Medical Center , Nashville , TN , USA.
² b Department of Pharmacology , Vanderbilt University , Nashville , TN , USA.

No abstract available

Keywords: Kir1.1; Kir7.1; drug discovery; high-throughput screening; inward rectifier potassium channel; mutagenesis; patch clamp electrophysiology; pharmacology; small-molecule.

MeSH terms

Heterocyclic Compounds, 1-Ring / pharmacology*
Humans
Mutation
Potassium Channel Blockers / pharmacology*
Potassium Channels, Inwardly Rectifying / antagonists & inhibitors*
Potassium Channels, Inwardly Rectifying / metabolism
Protein Conformation

Substances

7,13-bis(4-nitrobenzyl)-1,4,10-trioxa-7,13-diazacyclopentadecane
Heterocyclic Compounds, 1-Ring
Potassium Channel Blockers
Potassium Channels, Inwardly Rectifying