Effects of Adding Polysaccharides and Citric Acid into Sodium Dihydrogen Phosphate Mixing Solution on the Material Properties of Gelatin-Hybridized Calcium-Phosphate Cement

Keishi Kiminami; Toshiisa Konishi; Minori Mizumoto; Kohei Nagata; Michiyo Honda; Hidetoshi Arimura; Mamoru Aizawa

doi:10.3390/ma10080941

Effects of Adding Polysaccharides and Citric Acid into Sodium Dihydrogen Phosphate Mixing Solution on the Material Properties of Gelatin-Hybridized Calcium-Phosphate Cement

Materials (Basel). 2017 Aug 12;10(8):941. doi: 10.3390/ma10080941.

Authors

Keishi Kiminami^{1

2}, Toshiisa Konishi³, Minori Mizumoto⁴, Kohei Nagata⁵, Michiyo Honda⁶, Hidetoshi Arimura⁷, Mamoru Aizawa⁸

Affiliations

¹ Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan. keishi.kiminami@gunze.co.jp.
² GUNZE LIMITED, 1 Zeze, Aono-cho, Ayabe 623-8511, Japan. keishi.kiminami@gunze.co.jp.
³ Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, 3-1-1 Tsushima-naka, Kita-ku, Okayama 700-8530, Japan. toshiisak@cc.okayama-u.ac.jp.
⁴ Kanagawa Academy of Science and Technology, 3-2-1 Sakado, Takatsu-ku, Kawasaki 213-0012, Japan. mizumotomi@gmail.com.
⁵ Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan. nagata_k@meiji.ac.jp.
⁶ Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan. michiyoh@meiji.ac.jp.
⁷ GUNZE LIMITED, 1 Zeze, Aono-cho, Ayabe 623-8511, Japan. hidetoshi.arimura@gunze.co.jp.
⁸ Department of Applied Chemistry, School of Science and Technology, Meiji University, 1-1-1 Higashimita, Tama-ku, Kawasaki 214-8571, Japan. mamorua@meiji.ac.jp.

Abstract

We have succeeded in improving the material properties of a chelate-setting calcium-phosphate cement (CPC), which is composed of hydroxyapatite (HAp) the surface of which has been modified with inositol hexaphosphate (IP6) by adding α-tricalcium phosphate (α-TCP) powder. In order to create a novel chelate-setting CPC with sufficient bioresorbability, gelatin particles were added into the IP6-HAp/α-TCP cement system to modify the material properties. The effects of adding polysaccharides (chitosan, chondroitin sulfate, and sodium alginate) into the sodium dihydrogen phosphate mixing solution on the material properties of the gelatin-hybridized CPC were evaluated. The results of mechanical testing revealed that chondroitin sulfate would be the most suitable for fabricating the hybridized CPC with higher compressive strength. Moreover, further addition of an appropriate amount of citric acid could improve the anti-washout capability of the cement paste. In summary, a gelatin-hybridized IP6-HAp/α-TCP cement system prepared with a mixing solution containing chondroitin sulfate and citric acid is expected to be a beneficial CPC, with sufficient bioresorbability and material properties.

Keywords: Inositol phosphate; anti-washout capability; bioresorbability; calcium-phosphate cement; gelatin particles; mechanical property; α-tricalcium phosphate.