Effect of oral contraceptives on balance in women: A randomized controlled trial

Taiwan J Obstet Gynecol. 2017 Aug;56(4):463-466. doi: 10.1016/j.tjog.2017.02.003.

Abstract

Objective: To detect the effect of combined oral contraceptive pills (COC) on dynamic postural balance in healthy middle aged women.

Materials and methods: A prospective randomized controlled study included 200 patients classified into two groups. Group I received COC containing 30 μg of EE and 3 mg of drospirenone for 12 consecutive cycles and Group II received no treatment. Overall, medio-lateral and antero-posterior stability were measured using Biodex system after 12 months.

Results: There was a highly statistically significant difference between the 2 study groups regarding estradiol level (12.84 ± 1.96 vs. 38.86 ± 3.99, P value < 0.001) and progesterone level (0.52 ± 0.25 vs. 11.64 ± 4.53, P value < 0.001). There was a highly statistically significant difference between the 2 study groups regarding mediolateral stability (1.84 ± 0.23 vs. 2.40 ± 0.56, P value < 0.001), antereoposterior stability (1.91 ± 0.29 vs. 2.33 ± 0.61, P value < 0.001) or overall stability (2.42 ± 0.29 vs. 2.95 ± 0.53, P value < 0.001).

Conclusion: COC are effective method of contraception to improve postural balance and decrease risk of injury in normal and athletic women. NCT02855294.

Keywords: Combined oral contraceptive pills; Dynamic postural balance; Stability index.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Androstenes / pharmacology*
  • Athletes
  • Contraceptives, Oral, Combined / pharmacology*
  • Estradiol / blood
  • Ethinyl Estradiol / pharmacology*
  • Female
  • Humans
  • Postural Balance / drug effects*
  • Progesterone / blood
  • Progestins / pharmacology*
  • Prospective Studies
  • Young Adult

Substances

  • Androstenes
  • Contraceptives, Oral, Combined
  • Progestins
  • Ethinyl Estradiol
  • Progesterone
  • Estradiol
  • drospirenone

Associated data

  • ClinicalTrials.gov/NCT02855294