Nonmotor Symptoms in Essential Tremor and Other Tremor Disorders

Int Rev Neurobiol. 2017:134:1373-1396. doi: 10.1016/bs.irn.2017.05.010. Epub 2017 Jun 27.

Abstract

Tremor, like dystonia, is a term used at the phenomenological, syndromic, and aetiopathological level. Parkinsonian, essential, and dystonic tremor are the three most common tremor diagnoses encountered in clinical practice. Investigation of nonmotor symptoms in essential tremor and dystonic tremor syndromes is significantly hampered by the lack of clear clinical diagnostic criteria for these groups at a syndromic level, and the absence of biomarkers which allow definitive diagnosis at an aetiopathological level. Much work is needed in clarifying the motor features of these disorders in order to allow delineation of the nonmotor features of the most common tremor syndromes. With this limitation in mind, this chapter reviews what is known about nonmotor symptoms in these two tremor types. The final sections deal with nonmotor symptoms observed in patients with lesional tremor, thankfully a much more clearly defined albeit less common group of patients.

Keywords: Cerebellum; Dystonia; Dystonic tremor; Essential tremor; Holmes tremor; Lesional tremor; Nonmotor symptoms; Tremor.

Publication types

  • Review

MeSH terms

  • Cognitive Dysfunction / diagnosis
  • Cognitive Dysfunction / epidemiology
  • Cognitive Dysfunction / physiopathology
  • Essential Tremor / diagnosis*
  • Essential Tremor / epidemiology
  • Essential Tremor / physiopathology*
  • Humans
  • Mental Disorders / diagnosis
  • Mental Disorders / epidemiology
  • Mental Disorders / physiopathology
  • Parkinson Disease / diagnosis*
  • Parkinson Disease / epidemiology
  • Parkinson Disease / physiopathology*
  • Tremor / diagnosis
  • Tremor / epidemiology
  • Tremor / physiopathology